Multiple sclerosis (MS) often causes problems with cognition, which are also linked to motor symptoms. However, carrying out routine cognitive testing in clinical practice is complicated, because there is often a lack of time and trained personnel, and because frequently persons with MS feel cognitive symptoms but have normal cognitive test scores. Furthermore, the treatment of cognitive problems is complex: cognitive rehabilitation is promising, but a lot of questions on this topic remain unanswered and in practice this treatment is often difficult to carry out.
In this thesis we first explore smartphone-based tests as possible cognitive screening tools to support clinical practice, and investigate the differences between the cognitive symptoms that a patient feels and cognitive test scores. Next, we study the treatment of cognitive problems. We use telemedicine solutions and the link between cognitive and motor symptoms to investigate whether combined cognitive-motor telerehabilitation is a viable, and possibly even more effective, treatment option.