Cognitive-motor telerehabilitation in multiple sclerosis: CoMoTeMS study
What? 12-week telerehabilitation program
Who? Persons with MS between 18 and 65, with an EDSS score of less than 6.0 (i.e. who can walk minimum 100 meters without aid)
Where? 4 testing sessions in UZ Brussel/VUB Jette
The management of cognitive impairment is an important goal in the treatment of multiple sclerosis (MS). Both cognitive and motor rehabilitation have shown improvement of cognitive performance in MS, and research in the elderly indicates that a combined cognitive-motor approach may also be effective.
In the CoMoTeMS-trial patients with MS will receive 12 weeks of either a combined cognitive-motor telerehabilitation program or only cognitive or motor training. The primary outcome is a change in the digit span backwards, a test of working memory. Secondary outcomes are other cognitive changes (Brief International Cognitive Assessment for Multiple Sclerosis and Backward Corsi), Expanded Disability Status Scale (EDSS), 6-Minute Walk Test, 25-Foot Walk Test, 9-Hole Peg Test, anxiety and depression, fatigue, quality of life and cognitive and physical activity level. Furthermore, electroencephalography (both resting-state and task-related) and structural MRI's of the brain (T1, FLAIR, DTI and synthetic MRI) will be acquired before and after the training program.
We will assess:
- The effectiveness of the three training programs
- The mechanisms of improvement
- The predictors of treatment response
Questions? Do not hesitate to contact Delphine.Van.Laethem@vub.be.
